Walter Rossmanith
Principal Investigator:
Walter Rossmanith
Medical University of Vienna
Project title:
A tRNA methyltransferase and 5' endonuclease: molecular mechanisms of a multifunctional mitochondrial enzyme
Further collaborators:
Maria Selmer (Uppsala University)
Completed (01.01.2010 – 31.12.2013) 48 months


Transfer RNAs, the ubiquitous translational adapters of cellular protein synthesis, are synthesized as immature precursors. They have to undergo a number of processing and modification steps in order to become functional molecules. In human mitochondria, the subcellular factories responsible for energy production, a recently identified, novel type of enzyme complex is responsible for even two of these steps: the removal of extensions at the front end and chemical modification of a certain position within mitochondrial transfer RNA molecules. A subunit of the enzyme is moreover involved in the metabolism of certain amino acids and fatty acids. It is the primary aim of this project to elucidate the molecular-mechanistic basis and evolution of this unparalleled multiplex catalytic ability of an enzyme.


This site uses cookies. By continuing to browse the site, you are agreeing to our use of cookies. Click for details.