Life Sciences 2020 - Precision MedicineLS20-079

Closing the Loop in Hemodialysis: A Precision Medicine Approach


Principal Investigator:
Manfred Hecking
Institution:
Medical University of Vienna
Project title:
Closing the Loop in Hemodialysis: A Precision Medicine Approach
Collaborators:
Siegfried Wassertheurer (Austrian Institute of Technology GmbH) (Co-Principal Investigator)
Karl Mechtler (Forschungsinstitut für Molekulare Pathologie GmbH) (Co-Principal Investigator)
Status:
Ongoing (01.06.2021 – 31.05.2025)
Funding volume:
€ 868,540

 
Abstract: Fluid status and blood pressure (BP) are deranged in a variety of health disorders including kidney disease. Hemodialysis (HD) for kidney failure can inform human fluid and BP research in general. We previously identified patient clusters based on bioimpedance spectroscopy-derived fluid overload (BIS), BP, gender, comorbidities; we incorporated absolute blood volume (ABV) measurements by intradialytic blood volume monitoring (BVM) in response to dialysate bolus into clinical routine; and we analyzed the details of the renin angiotensin system (RAS). Aiming at improving patient outcomes far beyond kidney failure, we propose a 3-step project: (1) Developing an algorithm for ABV determination (N=98 patients); (2) A precision medicine registry combining BIS, 24h-ambulatory BP, ABV, focusing on RAS fingerprinting and dialysate/urinary proteomics, with qualitative patient interviews and hard clinical outcomes (N=200); (3) An interventional cross-over RCT, using the clustering developed from (1) & (2) and applying algorithm-assisted HD therapy in clinically challenging patients (fluid and BP extremes) based on BIS, BP, BVM/ABV, RAS, controlled by patient choice (N=50). Representing precision medicine per se, our approach closes the loop on BIS and BVM/ABV, offering an automated tool for HD patients in general. The precision clustering (including proteomics) will also generate pathophysiological knowledge on BP (high and low) and fluid (overload and depletion) beyond HD.
 

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