Marcin F. Osuchowski  Soheyl Bahrami
Principal Investigator:
Marcin F. Osuchowski Personal webpage
Ludwig Boltzmann Society
Age & gender related septic complications in trauma patients: individually tailored treatment during posttraumatic phase
Soheyl Bahrami (Ludwig Boltzmann Society) (Co-Principal Investigator) Personal webpage
Abgeschlossen (01.05.2008 – 30.04.2012) 48 Monate
€ 775.500


Sepsis is a complex syndrome with wide presentation of symptoms, hence it is
difficult to define, diagnose and treat. Among the numerous events that contribute
to the enhanced susceptibility of patients to infection, the decline of immune
function that accompanies aging is of critical importance. Moreover, the immune
defense capacity differs between males and females. We hypothesise that
lethality due to septic complications in patients with multiply trauma stems from
an improper, either hyper-or hypo-inflammatory, response and can be quelled not
by generalized but by an individual therapy tailored specifically to age and
gender. The proposed project addresses the mechanisms and prevention of
septic complications in young/aged and male/female patients with multiple
trauma. The project will be carried out in experimental animal models of trauma
and sepsis in an attempt to improve survival by age/gender related goal-directed
immune modulation.


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