Michael Dworzak  Veronika Sexl
Principal Investigator:
Michael Dworzak Personal webpage
St. Anna Kinderkrebsforschung
Flow cytometric signal typing for therapy response prediction in pediatric myeloid leukemia
Veronika Sexl (Medical University of Vienna) (Co-Principal Investigator) Personal webpage
Abgeschlossen (01.03.2008 – 29.02.2012) 48 Monate
€ 654.500


The rapidly expanding knowledge about the intracellular signaling pathways has
placed new small molecule compounds at the forefront of clinical research trials
in Leukemia, which either inhibit cell proliferation or activate cell death. The
conventional practice of therapy is about to radically change as a result of the
development of these new targeted agents. Yet, it is clear that a great amount of
work remains to be done to elucidate the mechanisms by which leukemic cells
respond to diverse agents and to determine the optimal settings in which patients
are bound to benefit maximally from new therapy options. This project aims at
developing methods based on flow cytometry to determine the intracellular
signaling status of individual leukemic cells to identify useful therapy options and
monitor treatment in leukemic patients.


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