Ischemia-reperfusion injuries (IRI) are a common complication in medicine. IRI
occurs when blood supply to tissues or organs is temporally interrupted and then
reintroduced again (reperfusion). In organ transplantation, IRI-induced injuries are
a major predictor for function and loss of organs; the important role of IRI has
also been shown in myocardial infarction, stroke and several surgical procedures.
Mechanisms leading to IRI are relatively well understood, although there is
currently no existing therapy or prevention. The aim of this project is the
development of an effective treatment using an endogenous enzyme system
(heme oxygenase-1) that has been shown in recent years to be a major
protective gene in ischemia-reperfusion injuries.