Sabine Zöchbauer-Müller
Principal Investigator:
Sabine Zöchbauer-Müller
Medical University of Vienna
Mapping of CpG island methylation and its prognostic relevance in lung cancer
Abgeschlossen (01.04.2008 – 31.03.2011) 36 Monate
€ 502.011


Aberrant methylation of 5' gene promoter regions is a frequent mechanism to
inactivate cancer-related genes and plays an important role in the pathogenesis
of lung cancer. This tumor type is the most common cause of death from cancer
worldwide. In this project we plan to investigate the methylation pattern of CpG
islands by combining immunoprecipitation of methylated DNA (MeDIP) with
microarray analysis in the whole genome of patients with non-small cell lung
cancer (NSCLC). The results will be compared with data from both disease-free
and overall survival of the patients. Aims of this project are 1. to identify genes so
far unknown to be inactivated by methylation, 2. to identifiy genes whose
methylation status is of prognostic relevance for NSCLC patients and 3. to
develop a test for determining the methylation status of prognostic relevant genes
in an easy and fast way.


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