Jürgen Sandkühler  Burkhard Gustorff
Principal Investigator:
Jürgen Sandkühler Personal webpage
Institution:
Medical University of Vienna
Projekttitel:
A novel role for opioids - Reversal of established hyperalgesia and chronic pain
ProjektpartnerInnen:
Burkhard Gustorff (Medical University of Vienna) (Co-Principal Investigator) Personal webpage
Status:
Abgeschlossen (01.03.2008 – 28.02.2011) 36 Monate
Fördersumme:
€ 780.925

 
Kurzzusammenfassung:

Pain is the major cause for seeking medical help and may severely threaten the
quality of life of many patients. In the central nervous system pain amplifier exist
which exaggerate pain. We have shown previously that synaptic long-term
potentiation in pain pathways contributes to pain amplification. We now
discovered that opioids may reverse synaptic long-term potentiation in animal
models and in human volunteers. In this project proposal we plan to explore this
novel opioid action and translate the experimental finding into a clinically useful
opioid therapy scheme to normalize pain sensitivity in selected groups of pain
patients. We thereby aim at an unprecedented causal therapy for some forms of
severe pain.

 

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